Suggest Treatment For Irritation And Difficulty In Focussing Despite Taking Vyvanse

My daughter is 13 years old and weighs 125lbs. She has been diagnosed with ADHD since the age of 6 by a professional. She is on a Vyvanse dosage of 50mg, but has only been on this dosage for a year and a half. Within the past few months I have noticed a change in her behavior. She seems distant, irritable after school, her grades are going down and says she is finding it harder to focus. We are also giving her a natural supplement called Attention along with her 50mg except for weekends. On the weekends when she is not on it, we have a totally different kid on our hands. She is laughing, talking and full of life. We have tried Ritalin, Adderall and Concerta. I am not sure if a different medication or dosage, whether lowering it or increasing it would help. We want the full of life kid we see on the weekends.