Hi, There are several possible causes for a lump or bump on the palm of your hand, including an insect bite, an allergic reaction, or a ganglion cyst. A thorough physical examination by a healthcare professional is necessary to determine the underlying cause and appropriate treatment. If the lump is itchy and uncomfortable, you can try applying a cool compress to the affected area or taking an over-the-counter antihistamine medication to help alleviate itching and inflammation. If the lump is due to an insect bite or allergic reaction, your healthcare provider may recommend a topical or oral corticosteroid medication to reduce swelling and inflammation. If the lump is a ganglion cyst, your healthcare provider may recommend observation or surgical removal, depending on the size and location of the cyst. It is important to seek medical attention if the lump is painful, rapidly growing, or accompanied by other symptoms such as fever or difficulty moving your hand. In some cases, a lump on the palm can be a sign of a more serious underlying condition, such as a tumor or infection. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician