Hi, Vicodin contains both hydrocodone and acetaminophen that is used to relieve moderate to severe pain. On the other hand, Percocet contains both oxycodone and acetaminophen which acts as a painkiller and used in the management of moderate to severe pain. But like other medications both these medication have some side effects of their own. They may cause low or lack of strength, lack of interest in activities, decreasing the ability of thinking, reacting or focusing, addiction, memory problems, tiredness, weakness, fatigue, constipation, dizziness, drowsiness, euphoria, nausea, vomiting, allergic reactions and many more. If someone experiences such type of side effects during taking these medication, then he or she should inform the prescribing doctor promptly for medical help. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Zubayer Alam, General And Family Physician