Hi, Unfortunately, there is no known treatment of palmoplantar keratoderma. However, different options of management can be tried with varying amount of relief in symptoms. Some of the options may be salt water soaks, emollients, topical keratolytics, topical retinoids, systemic retinoids (acitretin), topical vitamin D (calcipotriol), potent topical steroids, paring (cutting away of layers of skin) and surgery to remove skin followed by skin grafting. Choice of treatment should be under the guidance of a dermatologist taking into consideration of all pros and cons with regard to benefits vs risks. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Satnarain Bansal, General & Family Physician