Penile burning sensation is a feeling of burning, redness, warmth or swelling in the genitals, particularly in the penis. The sensation can be accompanied by blisters, pain, bloody or pink-colored urine (hematuria), itching, peeling, rash, scabbing, or swelling. Penile burning sensation can be extremely uncomfortable and create difficulty with urination, sexual relations, and daily activities. In addition to symptoms in and around your penis, it can be accompanied by generalized symptoms, such as flu-like symptoms (fatigue, fever, sore throat, headache, cough, aches and pains) and poor health in general. Only your doctor can advise whether any of these treatments are appropriate for your specific medical situation. Always discuss all treatment options with your doctor before making a decision, including whether to start or discontinue any treatment plan.