Hi, Severe pain and fatigue in the legs can be caused by a variety of underlying conditions, ranging from musculoskeletal problems to more serious medical conditions such as peripheral artery disease or neuropathy. Given your medical history of stage 3 Hepatitis C, it is important to see a healthcare provider to determine the underlying cause of your symptoms and receive appropriate treatment. In the meantime, you can try to manage your symptoms by: * Elevating your legs whenever possible * Avoiding standing or sitting for long periods * Doing gentle exercises such as walking or swimming to improve circulation and reduce fatigue * Wearing comfortable shoes with good support * Maintaining a healthy weight through a balanced diet and regular exercise It is important to follow your healthcare provider s instructions for any medication or treatment recommendations and attend all scheduled appointments for your condition. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician