I have E.D.S. I am female, 48 yrs. I also have been diagnosed with Fibromyalgia, Osteoarthritis also. I have had IBS for a few years now. For the past year I have been getting extreme stomach pain. At first I thought it may be something I ate. The pain comes on suddenly and it feels like I have to go, but I cant. It continues for up to 4 hrs. and then I am finally able to go and the pain finally goes away. My stools during these bouts are very loose. I alternate from constipation to diahrrea. I was scheduled for a colonoscopy. I was about to have this procedure, was all prepped and ready when the Dr. performing noticed i had written that i had E.D.S. He told me if I was aware of the risk of perforation. I hadn't. He told me it is a higher risk with type 4 E.D.S. but wanted me to be aware of the complications and results if it did happen. I am type 2, classical type. He ended up only doing a Flexible sigmondoscopy/lower colon because of the risk of perforation. He found 1 10 mm polyp which he biopsied but did not remove because of the wide stalk and known history of E.D.S. he found another 3 mm polyp which he resected and retrieved. Also internal hemorrhoids. I have an appt. with a colon rectal surgeon in few weeks for a consultation regarding the risk with finishing the colonoscopy in the upper colon. also to get results of polyps they found. I'm wondering if you know if the perforation they are talking about ONLY happens with type 4 E.D.S.? Should I be concerned. Can it possibly happen with other types of E.D.S.? Oh, there is colon cancer on my moms side. her two grandmothers died of this.