I,m 69 years old women , had thickening of the skin in the soles and later on in my palms ; then started getting fissurered and some times painful very rarely asoociated with oozing of blood . I have experienced many ways of treatment such az topical cream , ointments , getting vitamins ,homeopathy ,steroids both topical & systemic LASER therapy , had biopsy of the lesion to rull out malignancies and now after 2 and a half years I'm really getting tired of doing all these and no improvment . of couse there was times that it got better results ( specially after LASER therapy ) but it all started again and again . . now I'm here . . how do I treat them ?