Hello,
Thank you for your question. Infertility is defined as a couple's inability to become pregnancy within one year of
unprotected intercourse. The method of
ovulation induction selected by the clinician should be based upon the underlying cause of anovulation and the efficacy, costs, risks, burden of treatment, and potential complications associated with each method as they apply to the individual women.
For women with hypogonadotropic amenorrhea, we suggest pulsatile gonadotropin releasing hormone(GnRH) as first-line therapy in women with intact pituitary function in countries where it is available. Because clomiphene citrate is easy to administer, it is reasonable to give one course of clomiphene prior to initiating pulsatile GnRH. Gonadotropins are hormones (
luteinizing hormone (LH) and follical-stimulating hormone (FSH) that can be given in an injection to stimulate a women's ovaies to produce follicles, which contain an oocyte(egg). Gonadotropins are used for
ovarian stimulation in three main setting: to induce ovulation in women who do not ovulate on their own.
For women with
polycystic ovary syndrome (PCOS) undergoing ovulation induction, we suggest letrozole as first line therapy over clomiphene citrate, regardless of the patients body mass index(BMI). Before starting letrozole, the clinician must discuss that this use of the drug is approved for ovulation induction. For obese women with PCOS, we also suggest lifestyle changes and weight loss as an initial strategy to restore ovulatory cycles.
If oral ovulation induction agents are unsuccessful in women with PCOS, then gonadotropin therapy should be started. For women with
primary ovarian insufficiency no ovulation induction strategy has been shown to be effective. However,
in vitro fertilization with donor oocytes has high success rate. For women with hyperprolactinemic anovultaion, we suggest ovulation induction with dopamine agonist.
While there has been concern about possible increased risk of ovarian cancer with ovulation induction drugs, it appears that the risk may be due to the infertility itself rather than the medications used to treat it. However, because one study suggested an increase after 12 cycles of clomiphene citrate, women should not receive more than 12 cycles.
Go to see your doctor to find out what is you condition and check your husband as well if you already try some methods that is not effective.
Hope I have answered your query. Let me know if I can assist you further.
Best regards,
Dr. Heang Chan Raksmey, General and Family Physician.