Hello dear... Prolia is Denosumab, a fully human monoclonal antibody used for the treatment of osteoporosis and other conditions of reduced bone density, by preventing bone destruction. Studies have shown it to be very effective. Common side effects include constipation, rashes, joint pain, urinary and respiratory tract infections etc...but they are usually mild & well tolerated. Injectable form of Prolia can be taken once every 6 months. But whether to continue them life long will be decided by your Doctor by studying the bone density during the course of treatment. Also make sure that optimum calcium and vitamin D levels are maintained in the body before starting the therapy. Wishing you a Good Health. Let me know if I need to clarify further. Thanks & take care.