Hello.... Thanks for your query. Deseril is methylsergide, useful in preventing migraine attacks. Other drugs you have been prescribed include naproxen, NSAID for pain relief and topiramate to prevent migraine attacks. Deseril can definitely result in sleep disturbance though the negative thoughts seem untreated to the medication. You require a thorough psychiatric evaluation for an independent depressive illness and may require anti-depressants or psychotherapy (eg cognitive behavioural therapy) for the same. In addition you need to remember that stress can precipitate migraine attacks and you need to learn stress management techniques from a psychologist. Hope you found the information useful. Regards Dr Sundar Gnanavel Psychiatrist