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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Taking Udliv, Atocor, Rablet For High Liver Function Values. Reports Show High Triglycerides. Is Treatment Correct ?

Dear Sir,
I am 33 years old of weight 79 kg and height 1.74 m. I have been following my doctor's prescription of taking 1 no of Udliv 600 mg each before lunch and dinner , 1no of Atocor 10 mg after dinner and 1 no of Rablet 20 mg before breakfast since last 4 months. Before 4 months my SGPT was 107 and SGOT was 67. Recently I have found my SGPT and SGOT to be 62.2 and 54.4 . However, my triglyceride level is 204.2 mg/dl. Is my treatment going in proper direction? Moreover, I have been using Neurological medicine Desval-ER-500 since last 5 years due to epileptic disease. Does this medicine has any adverse effect in lever function? Please help....

regards,
AAAA
Wed, 24 Jul 2013
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General & Family Physician 's  Response
Welcome to HCM.Desval ER is known to cause liver toxicity,pancreatitis and other side effects .Since your enzyme levels are declining and there is no serious problem,it appears that it would be safe to continue your medication.Regular periodic liver function tests would be desirable .
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Internal Medicine Specialist Dr. Akhilesh Dubey's  Response
Hi,
Thanks for using Healthcaremagic,
You are having Epilepsy and taking DIVALPROEX SODIUM, this drug can certainly cause liver enzymes derangement but you are taking for last 5 years.

You should bring it to the notice of your Neurologist. If you are seizure free for last 5 year and regular in treating your problem even reduction in dose and observation may be done under supervision of the treating doctor.

Liver function needs to be monitored in patients taking this drug, if significant liver failure develops dose reduction or even withdrawal of drug is required.

You should discuss with treating doctor about your treatment. If by chance you use alcohol please avoid it completely.
Atorvastatin (Atocor) is another drug which can potentially cause elevated levels of SGOT and SGPT.
Please take care; you can always take second opinion.
Good Luck.
Dr.Akhilesh Dubey M.D.
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General & Family Physician Dr. Shekhar Deo's  Response
Hi, Welcome to HCM.

Most anti-epileptic medications including Desval (Valproic acid) affect liver function, however, based on the information you have given your liver function is certainly improving (decrease in SGPT and SGOT) indicating that your treatment is going in the right direction. However, your triglyceride level is still high.

I recommend increasing the dose of Atocor and repeating your lipid profile after couple of months. In this regard I will advise you to consult your primary physician and monitor your lipid profile as well as liver function.

Hope this helps.
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Taking Udliv, Atocor, Rablet For High Liver Function Values. Reports Show High Triglycerides. Is Treatment Correct ?

Welcome to HCM.Desval ER is known to cause liver toxicity,pancreatitis and other side effects .Since your enzyme levels are declining and there is no serious problem,it appears that it would be safe to continue your medication.Regular periodic liver function tests would be desirable .