Hi and thanks for this query. i am so sorry to hear about what is going on. I am sorry this service cannot accept reports but if you should ask it as a premium question, I will be able to add ore information in addition to this. Feel free about this. Increased ESR simple indicates that an inflammatory process is going on. It could be an infection, arthritis, cancer related, osteomyelitis, arteritis, anemia etc. A very detailed questioning, clinical and laboratory exams have to be done. This will orient and give a sense to what else should be done. I will not conclude that high ESR is diagnostic of cancer unless there are some other arguments in this light. Hope you find this helpful. If you can forward the report, i may provide more details. Otherwise, simply giving brough antibiotics ay not be the easy way out. Investigate and get the cause before rushing to treatment. What is problematic and not the treatment and unless you know what you are treating, you are treating nothing. I wish you and your wife the best out of this. Dr. Ditah, MD