Thank you, my 89 year old mother has a leg wound, that is not healing, she experiences nerve pain, after each dressing change (every other day) the home nurses are using a zinc wrap and uniboot(?) compression, she has just been prescibed the patch.....The placement is under the uniboot, so it will stay on longer than 12 hours at a time, I am concerned about her healthy skin being affected by the adhesive & active drug and that it will be inactive after 12 hrs but still in contact with her skin. Should we try it higher on the leg where there is no dressing? Try it under the uniboot dressing. Her skin is so fragile and I can't risk any further wound creating.