Hello I appreciate your query. Deviry contains medroxyprogesterone acetate Early studies suggest medroxyprogesterone may increase the risk for abnormal development of the baby s genitals when used in the first trimester of pregnancy. In addition there is risk of decreased birth weight . However, not all studies show an association between medroxyprogesterone use and abnormal genital development. Therefore, it is unclear how significant the risk truly is. One study showing lack of any side effects is as follows : http://www.ncbi.nlm.nih.gov/pubmed/3175947 For detailed reading , I suggest - http://www.otispregnancy.org/files/depotmedroxyprogesterone.pdf Moreover, you need to have regular antenatal surveillance, anomaly testing in the form of integrated screening for congenital anomalies, regular folic acid in first trimester, avoiding further teratogens , alcohol, smoking etc. All the best.