Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
159 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

Treated For RA. Taking Methtrexate. Inflammatory Markers Remain Elevated. Is This Effect Of Tablet?

I have RA and have been in treatment for 3 years My RA seems refractive to most treatment but am currently on methtrexate .5 sq weekly and humira sq weekly. I also take Tarka for b/p, folic acid, vitamin D and calcium , prednisone 5 mg daily and hydro codone 5/325 q 8 hrs as needed. Over the counter meds include 2 aleve each morning. My most recent lab studies indicate elevated ALT/SGPT - 55 reference range 5-41. My inflammatory markers remain elevated. mcv is elevated- 110 reference range (80-102), elevated mch 35( 27-34) and elevated mchc 17 (10-15%) The elevated liver enzyme, mcv,mch and mchc are new and I was wondering if my current meds could be the culprit. Can methotrexate affect liver enzymes these values? I will be getting follow up lab this week and will discuss with my rheumatologist But wanted to get some idea of where our discussion may lead based on these labs.
posted on Sun, 27 May 2012
Twitter Mon, 31 Mar 2014 Answered on
Twitter Tue, 1 Apr 2014 Last reviewed on
Report Abuse
Internal Medicine Specialist,  's  Response
Dear friend.

Welcome to HCM.

Rise in liver enzymes can be due to Methotrexate.

Rise in MCV is mostly due to Megaloblastic/ Pernicious anemia, but other serious issues can be there.
I advise you to get:
1. Vitamin B12 Levels
2. Folate levels
3. Complete hemogram and blood picture.

Review with reports

Stay Healthy.
I find this answer helpful
Note: For further follow up on digestive issues share your reports here and Click here.
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]
Share on
 

Related questions you may be interested in


Recent questions on Liver


Loading Online Doctors....
Treated For RA. Taking Methtrexate. Inflammatory Markers Remain Elevated. Is This Effect Of Tablet?

Dear friend. Welcome to HCM. Rise in liver enzymes can be due to Methotrexate. Rise in MCV is mostly due to Megaloblastic/ Pernicious anemia, but other serious issues can be there. I advise you to get: 1. Vitamin B12 Levels 2. Folate levels 3. Complete hemogram and blood picture. Review with reports Stay Healthy.