I have RA and have been in treatment for 3 years My RA seems refractive to most treatment but am currently on methtrexate .5 sq weekly and humira sq weekly. I also take Tarka for b/p, folic acid, vitamin D and calcium , prednisone 5 mg daily and hydro codone 5/325 q 8 hrs as needed. Over the counter meds include 2 aleve each morning. My most recent lab studies indicate elevated ALT/SGPT - 55 reference range 5-41. My inflammatory markers remain elevated. mcv is elevated- 110 reference range (80-102), elevated mch 35( 27-34) and elevated mchc 17 (10-15%) The elevated liver enzyme, mcv,mch and mchc are new and I was wondering if my current meds could be the culprit. Can methotrexate affect liver enzymes these values? I will be getting follow up lab this week and will discuss with my rheumatologist But wanted to get some idea of where our discussion may lead based on these labs.