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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Trying To Conceive. Diagnosed Homozygous C677t MTHFR. Prescribed Duphaston, How Long To Continue? Had Miscarriages Before

Hi I m 33 years old ttc I had 3 miscarriage ( all during 1st trimester ) my forth pregnancy completed ( i was on clexane 40 , progestrone, baby aspirin and prednisolone ) till I had preeclampsia at 29th week so they have to terminate the pregnancy the babies where died after spending 20 days in ICU , now I m ttc and was tested for a gene mutation MTHFR I m a homozygous C677t my doctor described me duphaston 10mg twice daily for ONlLY 10 days from16th to 25th and I should have intercourse during the ovulating days my question is what if I stopped duphaston and I was preg. Is this will affect the pregnancy is it better to complete the duphaston till I menstruate or it should be stopped then waiting for either menstruation or pregnancy?
Mon, 12 Nov 2012
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OBGYN 's  Response
Hi,
Thanks for the query.
Duphastone is a progesterone often prescribed to support the pregnancy. You can take progesterone from 16-25th day and then wait, if pregnancy is confirmed restart it again. Also take folic acid daily since you are planning.

Best wishes
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Trying To Conceive. Diagnosed Homozygous C677t MTHFR. Prescribed Duphaston, How Long To Continue? Had Miscarriages Before

Hi, Thanks for the query. Duphastone is a progesterone often prescribed to support the pregnancy. You can take progesterone from 16-25th day and then wait, if pregnancy is confirmed restart it again. Also take folic acid daily since you are planning. Best wishes