Is there evidence or research on long-term side effects of trazodone, specifically how such use might cause chronic urinary retention? I am a 58 year old male, and have been taking trazodone for nightime relaxation and sleep for over 15 years. I am suffering from uriniary retention and have been diagnosed with mild BPH and overactive bladder. No medications have helped my condition, including Jalyn for prostate, or VESIcare for OAB. Trazodone causes priapism and I m wondering if long term damage has been done, and what is the treatment for such damage?