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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Side Effects Of Civex And Pyzina 750?

Hi, My father age 59 yrs has beem recently having symptoma of lymph node tuberculosis. Having done a biopsy and microbiological test it showed lymph tb and not 100% sure. Therefore doc has started tb treatment and monitor his improvement. He is taking Civex (before food) & Pyzina 750 ( morning and evening). He is feeling too tired and feels sleepy. Pls advice what are the side effects of these tqblets and how can the side effects be treated. Regqrds Prasad
Sat, 8 Oct 2016
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General & Family Physician,  's  Response
Hi & Welcome to HCM.
I appreciate your concern for your beloved father.
The prescribed antituberculosis medications are generally safe and well tolerated. However the following side effects can occur.

1. R Cinex (Isoniazid+Rifampicin) can cause harmless reddish coloured urine, flu like symptoms, decreased platelet levels, neuritis (pain and tingling sensation in the hands and feet), nausea, vomiting, etc.

He needs Pyridoxine supplement to overcome the neuritis caused by Isoniazid.
2. Pyzina (Pyrazinamide) can cause pain and swelling in the joints (due to increased blood uric acid), nausea and vomiting.

Both of the above medications can cause yellowing of the skin or eyes (jaundice) fever, right sided abdominal pain due to liver toxicity. In this case, he must stop taking all the prescribed medications and consult his treating physician for an alternate but safe medications to treat his lymph node infection.

Regarding his tiredness or sleepiness, he needs to be examined by his treating doctor to rule out any underlying complications of tuberculosis or other diseases.

Hope the suggestions given above would be useful.
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What Are The Side Effects Of Civex And Pyzina 750?

Hi & Welcome to HCM. I appreciate your concern for your beloved father. The prescribed antituberculosis medications are generally safe and well tolerated. However the following side effects can occur. 1. R Cinex (Isoniazid+Rifampicin) can cause harmless reddish coloured urine, flu like symptoms, decreased platelet levels, neuritis (pain and tingling sensation in the hands and feet), nausea, vomiting, etc. He needs Pyridoxine supplement to overcome the neuritis caused by Isoniazid. 2. Pyzina (Pyrazinamide) can cause pain and swelling in the joints (due to increased blood uric acid), nausea and vomiting. Both of the above medications can cause yellowing of the skin or eyes (jaundice) fever, right sided abdominal pain due to liver toxicity. In this case, he must stop taking all the prescribed medications and consult his treating physician for an alternate but safe medications to treat his lymph node infection. Regarding his tiredness or sleepiness, he needs to be examined by his treating doctor to rule out any underlying complications of tuberculosis or other diseases. Hope the suggestions given above would be useful.