I am wondering which has the least side effects, Estrace Vaginal Cream, or Estring? It s always frightening to read the list of possible side effects. I am an otherwise healthy 66 year old woman. I have been on Yuvafem, but have found it more of a problem of late, due to my bodies inability to actually dissolve the pill. I asked my doctor about other possible medications to deal with atrophy. I also have fairly severe hot flashes that have been going on for 25 years. I don t expect either of these to help the power surges , but I would like the best one with least side effects for the rest. My doctor has suggest either of those I mentioned.