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What Are The Side Effects Of Tikosyn?
What percentage of Tikosyn patients have side affects listed as common . What percentage of patients have the more severe. One has to be hospitalized to go on Tikosyn. Is there any danger that the heart can suffer the same negative effects after 3 days. And danger if you suddenly stop taking Tikosyn
Thu, 8 Nov 2018
Hi,
Tikosyn is composed of 'Dofetilide', which is a class III antiarrhythmic agent.
It is used for the maintenance of sinus rhythm in individuals prone to the occurrence of atrial fibrillation and flutter arrhythmias.
Torsades de pointes (a specific type of abnormal heart rhythm that can lead to sudden cardiac death) is the most serious side effect of dofetilide therapy. The incidence is 0.3 - 10.5% and is dose-related, with increased incidence associated with higher doses.
The risk of inducing torsades de pointes can be decreased by taking precautions when initiating therapy, such as hospitalizing individuals for a minimum of three days for serial creatinine measurement, continuous telemetry monitoring and availability of cardiac resuscitation.
If Tikosyn needs to be discontinued to allow dosing of another potentially interacting drug(s), a washout period of at least two days should be followed before starting the other drug(s).
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Ashakiran S,
General & Family Physician
Tikosyn is composed of 'Dofetilide', which is a class III antiarrhythmic agent.
It is used for the maintenance of sinus rhythm in individuals prone to the occurrence of atrial fibrillation and flutter arrhythmias.
Torsades de pointes (a specific type of abnormal heart rhythm that can lead to sudden cardiac death) is the most serious side effect of dofetilide therapy. The incidence is 0.3 - 10.5% and is dose-related, with increased incidence associated with higher doses.
The risk of inducing torsades de pointes can be decreased by taking precautions when initiating therapy, such as hospitalizing individuals for a minimum of three days for serial creatinine measurement, continuous telemetry monitoring and availability of cardiac resuscitation.
If Tikosyn needs to be discontinued to allow dosing of another potentially interacting drug(s), a washout period of at least two days should be followed before starting the other drug(s).
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Ashakiran S,
General & Family Physician
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