What does an esophageal spasm feel like? I have GERD. I have had a chronic sore throat and was diagnosed with Barrett s Disease last year. Lately, I ve been having periodic thump sensations in the middle of my chest, mostly when I m sitting. Would that be spasms, or could it be something else? Note: I have had open heart surgery (Maze Cox IV) for Atrial Fib. I currently take Flecanide Acetate(100mg, 2X daily), Atenolol (25mg), and a baby aspirin daily, plus Omeprazole (40mg) and Montelukast Sodium (10mg) and a range of vitamins and minerals, including calcium. Thanks for your help and advise.