The symptoms of prostate cancer are A frequent need to urinate, especially at night Difficulty starting or stopping a stream of urine A weak or interrupted urinary stream Leaking of urine when laughing or coughing Inability to urinate standing up A painful or burning sensation during urination or ejaculation Blood in urine or semen These are not symptoms of the cancer itself; instead, they are caused by the blockage from the cancer growth in the prostate. They can also be caused by an enlarged, noncancerous prostate or by a urinary tract infection. Symptoms of advanced prostate cancer include: Dull, deep pain or stiffness in the pelvis, lower back, ribs, or upper thighs; pain in the bones of those areas Loss of weight and appetite, fatigue, nausea, or vomiting Swelling of the lower extremities Weakness or paralysis in the lower limbs, often with constipation Regards DR De