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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes A Sore With Oozing Blood On Legs After Taking Antibiotics?

Dr. at nursing home gave my husband an antibiotic for a urinary tract infection that caused his leg to get beet red and ooze blood in an area about 4 inches square where his pants leg was burned to his leg. It took a year in the plastic surgery dept. to grow skin from the edges until the area was covered, but the skin is very vulnerable. When the antibiotic dose finished the leg returned to normal. Now it s doing it again and the Dr. says it s not the antibiotic. The antibiotic starts with a c and seems familiar to people at dialysis. Have you ever seen such an allergy for an antibiotic?
Mon, 14 Nov 2016
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General & Family Physician,  's  Response
Hi & Welcome.
I appreciate your concern for your beloved husband and sorry to know his skin problem which seems to be drug induced.

Based on the history given he seems to have developed a harmful skin condition called toxic epidermal necrolysis.

It is a potentially life-threatening skin disorder characterized by widespread redness of the skin, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death (see the image below).

Sulfonamide containing antibiotic Cotrimoxizole which is commonly prescribed to treat urinary tract infection appears to be the cause for his skin problem which occurs during the first 4 weeks of antibiotic therapy, usually between 1 and 3 weeks.

I have seen a few cases of antibiotic induced skin problems in my practice.
Please see that he avoids taking Sulfonamide containing antibiotics in future.
Hope this answers your query.
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What Causes A Sore With Oozing Blood On Legs After Taking Antibiotics?

Hi & Welcome. I appreciate your concern for your beloved husband and sorry to know his skin problem which seems to be drug induced. Based on the history given he seems to have developed a harmful skin condition called toxic epidermal necrolysis. It is a potentially life-threatening skin disorder characterized by widespread redness of the skin, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death (see the image below). Sulfonamide containing antibiotic Cotrimoxizole which is commonly prescribed to treat urinary tract infection appears to be the cause for his skin problem which occurs during the first 4 weeks of antibiotic therapy, usually between 1 and 3 weeks. I have seen a few cases of antibiotic induced skin problems in my practice. Please see that he avoids taking Sulfonamide containing antibiotics in future. Hope this answers your query.