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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Acute Vitamin B12 Deficiency After Combiflam Overdose?

my fiancee took ten combiflam tablets together an year ago. 2 months later she was detected with acute vitamin b12 deficiency. She keeps on falling ill after evry 2 months. What are the possible side effects of combiflam overdose and is her continous illness related to it any way?
Wed, 26 Feb 2020
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General & Family Physician 's  Response
Hi,

Combiflam is a combination of non-steroidal anti-inflammatory drugs (ibuprofen-400 mg and paracetamol) commonly used to treat mild to moderate pain associated with headache, toothache, musculoskeletal disorders, and dysmenorrhea. If taken in larger doses it may cause abdominal pain, vomiting, bleeding, and liver dysfunction which can be serious. It is not known to cause vitamin-B12 deficiency as such. However, vitamin-B12 can occur due to strict vegan diet, decreased absorption from the intestines, or pernicious anemia. She needs to be thoroughly investigated to rule out underlying cause of deficiency and its remedy accordingly.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Mohammed Taher Ali, General & Family Physician
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What Causes Acute Vitamin B12 Deficiency After Combiflam Overdose?

Hi, Combiflam is a combination of non-steroidal anti-inflammatory drugs (ibuprofen-400 mg and paracetamol) commonly used to treat mild to moderate pain associated with headache, toothache, musculoskeletal disorders, and dysmenorrhea. If taken in larger doses it may cause abdominal pain, vomiting, bleeding, and liver dysfunction which can be serious. It is not known to cause vitamin-B12 deficiency as such. However, vitamin-B12 can occur due to strict vegan diet, decreased absorption from the intestines, or pernicious anemia. She needs to be thoroughly investigated to rule out underlying cause of deficiency and its remedy accordingly. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali, General & Family Physician