Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. There can be alto of causes for chest pain,the most concerning is if the pain is of cardiac origin, that would have been great if you could have told us more about the pain, what ever if the pain is diffused or is associated with sweating or shortness of breath or any concern that it could be cardiac one please do not hesitate to see your doctor in this regarding Prednisolone, it does not cause directly the pain but it can cause gastritis, which can give us chest pain that is more in the center over the stomach , if it looks like this I would advise to stop it, and use some antacids. Other common causes of chest pain is from the muscles, that is if it occur with some heavy work or trauma to the the chest. it may be unrelated to the drug. I would like some more details of the pain if possible if you cannot see your doctor Hope I have answered your query. Let me know if I can assist you further.