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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Constipation And Excess Sweating While On Prazosin And Mirtazapine?

I have been diagnosed with major depression, PTSD and anxiety. I am currently taking Buspirone (15mg 1 po prn q TID) AND Effexor XR (300mg q day). Mirtazipine has also been added to my medication regimen (I have yet to start this medication) and I have prescribed Prazosin (1mg q HS for night terrors/rarely taken). I have currently been having an increase in sweating (often excessive whereas others are not hot ), vision changes, constipation (approx. 10 days without BM) and now I am experiencing nocturnal leg cramps and leg twitching. Could these symptoms be related to these medications? I am 48 yrs old, and I have been thinking that the diaphoresis is related to hormonal changes? I am not sure as to what course of action I need at this time, but am worried that I may be developing serotonin syndrome.
posted on Mon, 26 Oct 2015
Twitter Sat, 4 Apr 2020 Answered on
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General Surgeon,  's  Response
Hello,

The excess sweating and constipation are not part of serotonin syndrome but the side effects of the drugs consumed for PTSD and anxiety. The Prazosin is an alpha receptor blocker and hence there is increasein the autonomic systemic response causing excess sweating. The constipation is common side effect of Mirtazapine, a selective serotonin reuptake inhibitor. All that is needed to settle the issue is get dose adjustment with your treating doctor for current doses consumed.

Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Bhagyesh V. Patel, General Surgeon
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What Causes Constipation And Excess Sweating While On Prazosin And Mirtazapine?

Hello, The excess sweating and constipation are not part of serotonin syndrome but the side effects of the drugs consumed for PTSD and anxiety. The Prazosin is an alpha receptor blocker and hence there is increasein the autonomic systemic response causing excess sweating. The constipation is common side effect of Mirtazapine, a selective serotonin reuptake inhibitor. All that is needed to settle the issue is get dose adjustment with your treating doctor for current doses consumed. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Bhagyesh V. Patel, General Surgeon