Hello , and thank you for being available ! I just switched blood pressure meds . I was taking metoprolol-hydrochloric for ten years...it stopped lowering my blood pressure and lowered my pulse to the 40 zone. I ve taken two newly prescribed pills, hydrochlorothiazide.25...felt great during the day..by evening my hands and right knee and shoulder cramped up so badly that I didn t take the pill today...My research tells me it depleted my potassium, and lowered my sodium..I think both had been low already....maybe a potassium supplement with just half a pill? It did make me feel good ,and my pulse was in the high 80 s...I m 65,healthy in every other area...a bit overweight..have had a very difficult ten years.....