Dr. Hanif warmly Welcomes you! Thanks for consulting at my virtual clinic. I have carefully worked through your case, and I can realize your health worries. Being your physician, I assure you not to worry as I will take care all of your medical concerns.   Meditation will help you. Keep relax as much as you can. Dont take tensions of work place to home. Try different timings of sexual intercourse. It will give happiness to you. Its not actually the rougher skin. It seems to have damaged the small nerve endings on the skin. Please consult a physician and get your blood pressure, fasting blood sugar levels, fasting lipid profile, thyroid functions, all checked. These imbalances/diseases may also cause this insensitivity and damage to the nerve endings. Nothing needed to apply topically, nor will it be pf any benefit. You may take capsule Perfectil 1 daily. Hope it helps. If you need further, detailed and quick assistance related to any health issues, feel free to ask me a question directly from my profile. Have a wonderful time ahead. Please don t forget to give five star rating, to help me assist you always in a better way. Click on thanks if you find this answer helpful. Please, write a review on my profile, about your experience with me.   Best Regards! DR. MUHAMMAD M. HANIF USA