I have edema in both legs and ankles and weight gain in stomach area also. I was prescribed Omeprazole 20 mg 2 pills per day and I also take Lisinapril 10 mg for essential high blood pressure. I have had issues with constipation and have been taking ducosate daily. I am thinking that over use of the ducosate may be causing the edema and maybe the Omeprazole also. I also get flushing, weakness, sometimes blurred vision. I have a high hernia which is why I have been prescribed the Omeprazole. I use to take Flodotine over the counter at the beginning of my dx of the high henial hernia with no problem. I had a recent cardiac stress test and everything showed up normal. I had a recent endoscopy and my 4cm hernia has not changed, no cancer, no food allergies. I had a colonoscopy in 2014 with no colon cancer or polyps detected. I also have had issues with globulus feeling in my neck. I do have hypothyroid and I am taking 25mcg of thyroid medication. I am thinking maybe of stopping the Omeprazole and going back to taking the Flodotine and stopping the Ducosate but keep taking the clear lax. The constipation issues started when I quit taking the Thyroid medication and started taking Porcine Thyroid supplement for over a year. The Porcine Thyroid was controlling my Thyroid as when I had my Lab test after I ran out and could not purchase anymore the doctor prescribed me the 25mcg of Thyroid medication based on the results of my lab test.