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Dr. Andrew Rynne
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Dr. Andrew Rynne

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What Causes Elevated Anti-TTG Levels In Case Of Celiac Disease?

I was in the hospital for a very low phosphorus (1.0) and low potassium (3.0). My doctor took a celiac panel blood test and I had an anti-tissue transglutaminase of 107. A small bowel biopsy was normal. Two months later, my anti-tissue transglutaminase level shot up to >300. Does anyone have any idea what this could mean? My GP and GI MD are at a loss. The GI doc said he's baffled as there is such a high correlation between anti-ttg and celiac. I don't know what to do next.....



Any ideas would be appreciated. Thanks!
Tue, 24 Apr 2018
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Internal Medicine Specialist,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

Yes, if tTG is positive, it means suggestive of celiac disease.

Symptomatic patients duodenal biopsy can be avoided if anti-tTG level is more than 100 U/mL (kit value of >10 as positive).9 Value of 10 times of normal limit was associated with villous atrophy of the GI tract mucosa and more severe clinical presentations with sensitivity and specificity of 98% and 99%, respectively.

If you're asymptomatic with negetive biopsy report then need to be followed. So, if you're symptomatic please consult your gastroentrologist who will examine and treat you accordingly.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Penchila Prasad Kandikattu
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What Causes Elevated Anti-TTG Levels In Case Of Celiac Disease?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Yes, if tTG is positive, it means suggestive of celiac disease. Symptomatic patients duodenal biopsy can be avoided if anti-tTG level is more than 100 U/mL (kit value of 10 as positive).9 Value of 10 times of normal limit was associated with villous atrophy of the GI tract mucosa and more severe clinical presentations with sensitivity and specificity of 98% and 99%, respectively. If you re asymptomatic with negetive biopsy report then need to be followed. So, if you re symptomatic please consult your gastroentrologist who will examine and treat you accordingly. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Penchila Prasad Kandikattu