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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Esophageal Erosion In Spite Of Taking Omeprazole?

I have been diagnosed with oesophagus distal end erosion and fundus erosion 6 months ago. I am on osmeoprazole 80 mg per day. But still the symptoms persist. Can this conditions be cured completely? I am really depressed , since I am on constant medication. What are the chances of developing oesophagal cancer?
Tue, 9 Feb 2016
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General & Family Physician,  's  Response
I understand your concern. Most reflux events occur during transient lower oesophageal sphincter relaxations (TLESRs) during night/ lying down positions.

treatment options available:
1) Common strategies for proton pump inhibitors (PPI-refractory GERD) are to increase the PPI dose or to change to an alternative PPI
2) GABA B agonists (baclofen or arbaclofen) - to prevent sphincter relaxations
3) Laparoscopic fundoplication - prevents all forms of reflux.
4) highly selective vagotomy - to stop acid production completely.
Please consult your doctor before taking further steps
Hope i answered your questions.
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What Causes Esophageal Erosion In Spite Of Taking Omeprazole?

I understand your concern. Most reflux events occur during transient lower oesophageal sphincter relaxations (TLESRs) during night/ lying down positions. treatment options available: 1) Common strategies for proton pump inhibitors (PPI-refractory GERD) are to increase the PPI dose or to change to an alternative PPI 2) GABA B agonists (baclofen or arbaclofen) - to prevent sphincter relaxations 3) Laparoscopic fundoplication - prevents all forms of reflux. 4) highly selective vagotomy - to stop acid production completely. Please consult your doctor before taking further steps Hope i answered your questions.