Sign-in to Ask A Doctor - 24x7
OR
Sign in with GoogleGet your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
What Causes Excessive Sweating While On Glyburide?
I just turned 70 (female), diagnosed with Type 2 diabetes in Dec. 2016. Weigh 220, height 5 7.5 . Originally put on metformin which made me nauseous. Switched to glyburide 2.5 mg qd. Weight loss extremely difficult (10# in 3.5 months), greatly increased sweating. Is glyburide safe for a female of my age? Should/could I be on anything else?
Thu, 8 Jun 2017
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.
There are several options for oral drugs for people with type 2 diabetes mellitus, but the most commonly used are:
Biguanida group that is metformin.
Second generation sulfonylureas (SFUs) are: glyburide (glibenclamide), gliclazide, glimepiride, and glipizide.
From several studies about the second generation sulfonylureas mentioned that:
Compared with other SFUs, glyburide has been associated with an increased risk of severe hypoglycemia, especially in the elderly. Evidence show the increased relative risk of hypoglycemia and the resulting harm with use of glibenclamide versus any of the other second generation SFUs, particularly gliclazide and glipizide. The data unequivocally recommends against the use of glibenclamide in older people.
Based on a review of safety, efficacy, cost, and NEML (Nasional Essential Medicines List) availability of glibenclamide, gliclazide, glipizide, and glimepiride, the recommendations are as follow:
1. Glibenclamide 2.5 mg and 5 mg tablets should remain on the EML (Essential Medicine List) with age restriction recommending against use in people older than 60 years of age.
2. Gliclazide 80 mg tablet should be added to the EML for use in the older with type 2 diabetes, indicate that other second general SFUs (other than glibenclamide) are an acceptable alternative.
My advice is that you can choose another SFUs class medication, suitable for your age.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Lili Sitanggang
I have reviewed your query and here is my advice.
There are several options for oral drugs for people with type 2 diabetes mellitus, but the most commonly used are:
Biguanida group that is metformin.
Second generation sulfonylureas (SFUs) are: glyburide (glibenclamide), gliclazide, glimepiride, and glipizide.
From several studies about the second generation sulfonylureas mentioned that:
Compared with other SFUs, glyburide has been associated with an increased risk of severe hypoglycemia, especially in the elderly. Evidence show the increased relative risk of hypoglycemia and the resulting harm with use of glibenclamide versus any of the other second generation SFUs, particularly gliclazide and glipizide. The data unequivocally recommends against the use of glibenclamide in older people.
Based on a review of safety, efficacy, cost, and NEML (Nasional Essential Medicines List) availability of glibenclamide, gliclazide, glipizide, and glimepiride, the recommendations are as follow:
1. Glibenclamide 2.5 mg and 5 mg tablets should remain on the EML (Essential Medicine List) with age restriction recommending against use in people older than 60 years of age.
2. Gliclazide 80 mg tablet should be added to the EML for use in the older with type 2 diabetes, indicate that other second general SFUs (other than glibenclamide) are an acceptable alternative.
My advice is that you can choose another SFUs class medication, suitable for your age.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Lili Sitanggang
I find this answer helpful
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer.
For a more detailed, immediate answer, try our premium service
[Sample answer]
Related questions you may be interested in
Loading Online Doctors....