Hello, please don t think that I m crazy for asking you this question, but every evening, usually beginning late afternoon around 4 or 5 o clock, I begin feeling extremely tired and sick. Usually, feelings of despair become greater then. I have taken Pramipexole for about 2 years for RLS and recently switched to the generic of Requip. I feel as if I m losing my mind. Any ideas that can direct me to help? Thank You, Ray B