Thank you for asking on HealthcareMagic.com. I have gone through your case and I can understand your concern. I would say that weakness may be caused from all these drugs separately or together (polypharmacy), but muscle discomfort indicates for Pravastatin' side effect. In rare cases, pravastatin can cause a severe condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease. I would suggest to see your treatment doctor for follow up. Please don't forget to give your valuable feedback and five star rating, to help me assist you in a better way. Click at 'I Find This Answer Helpful too'. Please, write a review about your experience with me.