Hi. I was recently started on sertraline for depression by my primary, maybe 4 days ago. Have been on suboxone for about a month and a half. I also,take bupropion but have been on that a very long time, over 10 years. I was doing alright with the suboxone though I m not crazy about the way it makes me feel. But since I started the Zoloft I just don t feel well. Mentally foggy, queasy, slow but anxious at the same time, almost like the sub isn t working as well. So I m wondering if there are drug interactions between these 2 drugs causing my problem.