62 year old female with : Headache with cold extremities. Flares up every few weeks ( from weekly to every 3-4 weeks) feeling as if I m getting flu. Lasts from 2-5 days. Sometimes accompanied with difficulty in breathing deeply, although no severe chest pain ( experienced pain just a few times) no sweating or numbness in arms. ECG normal. Chest scan normal. I have extremely dry eyes, require drops several times daily. High blood pressure (ave 138/95) with severe reactions to all medications prescribed, high cholesterol with severe reaction to prescribed statins. Goitre that increases and decreases in size randomly. Red rash across face. Occasional aching in hips, knees, hands. Extreme exhaustion. 14 months ago I could walk 3-4 miles and swam 3 times per week. Now I can walk half a mile, one on a good day, with effort. All recent blood tests were normal, except high cholesterol and elevated ANA. I weigh 72 kilos. Do not smoke or drink alcohol. Vegetarian for 50 years. Supplements taken B12 and folic acid after low B12 identified last year.