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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes High ANA Levels While Having Multiple Sclerosis?

I am 53 years old and have had MS for at least15 years. I went through the first round of Limtrada about 6 months ago. It seems to help a bit but there are times that I still have the same symptoms. I just had allot of blood work done and my ana was positive. I was already checked for Lupus about 10 years ago. Would that also come up positive with MS? I am on social security and it is the end of the month and I am out of funds. Sorry for waisting you time.
Mon, 8 Apr 2019
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General & Family Physician,  's  Response
Hello,

About 15% of MS patients are positive for ANA upon the first analysis. In non-autoimmune neurological diseases, the prevalence of ANA positivity was 6.1%.

ANA titers became normal in 94.7% of the MS patients over a mean maximum period of 22.5 +/- 19.2 months.

Because ANA fluctuates in MS, the titers of other circulating autoantibodies should be interpreted cautiously both when discussing etiopathogenetic hypotheses and when diagnosing associated diseases.

The diagnostic usefulness of ANA determination in MS is low.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr AJEET SINGH, General & Family Physician
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What Causes High ANA Levels While Having Multiple Sclerosis?

Hello, About 15% of MS patients are positive for ANA upon the first analysis. In non-autoimmune neurological diseases, the prevalence of ANA positivity was 6.1%. ANA titers became normal in 94.7% of the MS patients over a mean maximum period of 22.5 +/- 19.2 months. Because ANA fluctuates in MS, the titers of other circulating autoantibodies should be interpreted cautiously both when discussing etiopathogenetic hypotheses and when diagnosing associated diseases. The diagnostic usefulness of ANA determination in MS is low. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr AJEET SINGH, General & Family Physician