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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Hot Flashes After Taking Leuprolide Shots?

I have had two injections of leuprolide SyKt 22.5 mg. One on 3 Jan 2017 and the second 4Apr 2017.This was in conjunction with 40 radiation treatments (every weekday) from the second week in April until the third week in June.Ever since I have had hot flashes every 2 to 3 hours.My treatments are complete. When can I expect the hot flashed to cease?
Sat, 25 Aug 2018
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Oncologist, Surgical,  's  Response
Hello,

Leuprolide is known to cause hot flushes as a side effect. So, be rest assured that it is not something unknown that you are facing. This is seen in nearly 70% of the patients on GnRH analogues (one of which is Leuprolide). Most often than not it disappears within a few months to a year. But only in some rare instance it can persist for longer periods too. Unfortunately it is not predictable.

If this is debilitating you, you can always get treated for this with drugs. There are hormonal (like Megesterol, Medroxyprogesterone) and non-hormonal agents (Clonidine, Gabapentin) described to treat the hot flushes if its is significantly disturbing you.

Before embarking upon such treatment it is advisable to meet your physician.

Hope I have answered your query. Let me know if I can assist you further.
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What Causes Hot Flashes After Taking Leuprolide Shots?

Hello, Leuprolide is known to cause hot flushes as a side effect. So, be rest assured that it is not something unknown that you are facing. This is seen in nearly 70% of the patients on GnRH analogues (one of which is Leuprolide). Most often than not it disappears within a few months to a year. But only in some rare instance it can persist for longer periods too. Unfortunately it is not predictable. If this is debilitating you, you can always get treated for this with drugs. There are hormonal (like Megesterol, Medroxyprogesterone) and non-hormonal agents (Clonidine, Gabapentin) described to treat the hot flushes if its is significantly disturbing you. Before embarking upon such treatment it is advisable to meet your physician. Hope I have answered your query. Let me know if I can assist you further.