Hello . welcome to HCM. Your granny had what is called as accelerated hypertension. It is a medical emergency and requires immediate but gradual lowering of BP. A BP of 280/80 could have caused a blood vessel in the brain to rupture and may have lead to a stroke. Fortunately nothing like that happened. This also implies that she has suffered from high BP for a long time now, just not being diagnosed. With the medications the BP has reached an acceptable range although still slightly high. She is on 4 medications for BP amlopress at and tazloc H contain two combination of medications each) means she has got resistant hypertension. High BP usually affects target organs like brain, heart , kidneys and retina of the eye. She has to get these organs checked up. I recommend a 2 d echo and a ECG for cardiac evaluation. For the kidneys I recommend a serum creatinine levels and a renal artery Doppler. For the retina I recommend you see an opthalmologist. There is no serious complications expected if she is compliant on the medications and BP remains controlled. But the target organ damage must be assessed. Wishing her good health Regards.