My mother is 89 and on hospice care for advanced A.D. she has developed, over past year, an indentation on the top of her skull running left to right about three inches back from the front of the scalp. She has several large nodules on her thyroid, but her endocrinologist declined to pursue with needle biopsy or surgery due to her age and advanced disease, A.D. what do you think could be the cause of the changes in the top of her skull, indentation. She also has had significant loss in brain mass in past 12 years per MRI studies ren years apart.