HI - I have had incidents through the years where I would get a knot in my back that would shoot sharp pain into my head. When I would rub the knot, the pain would get more intense, and I d have to take a lot of pain medicine for several days before it would subside. I tried carisoprodol and it used to help, but doesn t any more. Recently, I ve been having the same sharp pain in my thighs, stemming from a small knot in my thigh muscles (front). I m hoping this is nothing chronic, but haven t done much to induce this. I wonder if it s sciatica related because when I sit on my bed for hours studying with my legs out in front of me, sciatica kicks in and I ve been doing that some lately. Hoping it s not MS, MD, or something else bad like that. Any ideas? Thanks!