Hi Thanks for posting your query on HCM Leg cramps at night could be caused by many medical conditions.Some possible causes may include: -Inadequate blood supply -Nerve compression/peripheral neuropathy -Ionic imbalances like low calcium, low magnesium, low potasium -Exercising, injury, or overuse of muscles -Exposure to cold temperatures -Dehydration -Vitamin deficiency I will suggest you see the Doctor for examination and investigations.Tests that may help identify the cause of your symptoms include: full blood count, ESR, serum electrolytes, fasting blood sugar. Your treatment will depend on the underlying cause.In the meantime, i will advise you try the following: *Stretch and massage regularly *Apply heat or cold *Drink enough water *Healthy/balanced diet with enough vegetables *If pain intense, you may add a pain drug like aceclofenac and a myorelaxant like miorel. Hope this will you Best regards