Hi. Thanks for your query. Noted the history and understood your concerns. Since you are taking Vynase for 2 years but got the loose stools recently indicate that these are not connected for sure. Secondly Probiotics helped you means there is an intestinal problem. Hence I would advise you the following in such a situation: Get the stool tests for for 2 consecutive days. Get the blood tests for CBC, thyroid and liver functions and any other tests as advised by your Doctor after a proper clinical evaluation and examination. All these will point to the proper cause. Get a course of an antibiotic, metronidazole and probiotics for 5 days. If you get the result well, have proper homemade foods , boiled and cooled water only to avoid recurrence. If there is not much of a relief then you need an opinion of a Gastroenterologist and further tests like colonoscopy and CT scan of the abdomen to get a proper diagnosis to be treated accordingly. If all the tests are normal then consider IBS that is Irritable Bowel Syndrome as the probable cause; reduce stress and anxiety and get an appropriate symptomatic treatment.