Hi,
In summary, you are complaining of gradually progressive weakness and decreased sensation since 12 years ago. Also you have some breathing and (may be) swallowing problems. You had lumbosacral and thoracic MRI study which are unremarkable but you did not mention a cervical MRI.
What you mentioned as the muscular seizure is more probably muscular
fasciculation (local twitching of the muscles.)
You did not mention if you have done an Electromyograhy and
Nerve Conduction Study (EMG & NCS) test or not.
-There are a lot of conditions that could explain your situation:
1-
Peripheral nervous system problems
2- Motor Neuron Disorders
3- Myopathies (less likely)
The first and most important test that you have not to mention is an EMG & NCS (see above) to reveal any peripheral nervous system (
polyneuropathy) or
Motor Neuron disease. This is very important that an expert Physiatrist or
neurologist does this test. You should also do some other blood tests such as Vit B12 level as severe B12 deficiency can mimic your symptoms.
Overall, there some of the etiologies for your condition are acquired and some others are genetically inherited. Some of the acquired etiologies have specific treatment and if you do not recognize them as soon as possible, they will induce irreversible damage.
Above all the things that I mentioned, a detailed physical examination can help that unfortunately, I cannot make it for you. Please refer to a Physiatrist or a neurologist and ask them to perform and EMG & NCS test and order a cervical MRI as well as some blood tests including Vit B12, thyroid function test. Also, if you use alcohol, please tell them as
alcohol abuse can also damage the peripheral nerves seriously.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Hooman Mahmoudi,
Neurologist