my brother is a level one manic / depresive patient, currently on seroquel, lamotrigine and depakote. these drugs seem not to work, he is at this time manic and seems to be short circuited. he used to be on Lithium and seroquel but had some kidney issues. he is ok with the kidney s. I have been caring for my brother for many years, when he was in the crisis center I discovered that he was given trazedone along with the seroquel and his brain short circuited are any of the above meds, lamotrigine or depakote antidepresants?