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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Muscle Pain In The Lower Extremities While On Pravastatin?

Recently (December) my dosage of Pravastatin was increased from 40mg to 80mg. Now I have noticed over the past 2 to 3 weeks I am experiencing more muscle pain in my lower extremities. Didn t notice these symptoms when my dosage was 40mg or at least not as intense. At one time I was on Lipitor and had to stop taking it because of joint pain in both my knees. ( a few yrs ago). What is your suggestion?
Tue, 18 Apr 2017
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General & Family Physician 's  Response
Hi, I had gone through your question and understand your concerns.

Statins can cause muscle pain. The risk of muscle injury increases when certain other medications are taken with statins. For example, if you take a combination of a statin and a fibrate -- another cholesterol-reducing drug -- the risk of muscle damage increases greatly compared to someone who takes a statin alone.

If you experience any unexplained joint or muscle pain, tenderness, or weakness while taking statins, you should call your doctor immediately.
So you will have to discontinue the drug. Pregnant women or those with active or chronic liver disease should not use statins.

Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. I will be happy to answer your questions.

Wishing you good health.
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What Causes Muscle Pain In The Lower Extremities While On Pravastatin?

Hi, I had gone through your question and understand your concerns. Statins can cause muscle pain. The risk of muscle injury increases when certain other medications are taken with statins. For example, if you take a combination of a statin and a fibrate -- another cholesterol-reducing drug -- the risk of muscle damage increases greatly compared to someone who takes a statin alone. If you experience any unexplained joint or muscle pain, tenderness, or weakness while taking statins, you should call your doctor immediately. So you will have to discontinue the drug. Pregnant women or those with active or chronic liver disease should not use statins. Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. I will be happy to answer your questions. Wishing you good health.