Hi, From what you have mentioned, it seems the person you are talking about is suffering from some sort of anxiety disorder. Further information will be required to specify the type of anxiety disorder. Feeling uncomfortable outside home, avoiding people can be suggestive of social phobia as well as agoraphobia. Remaining preoccupied with negative things, and worrying about each and every thing can be suggestive of generalised anxiety. It would be advisable to seek a psychiatric consultation for detailed evaluation. Treatment with medications like paroxetine can be helpful. Another option of treatment will be cognitive behavior therapy which will consist of sessions focusing on learning relaxation as well as helping change the maladaptive thinking pattern a person has which causes anxiety. Hope that this information was helpful. Best wishes.