If impetigo is confirmed, it can usually be effectively treated with antibiotics, which may be prescribed in the form of a cream (topical antibiotics) or as tablets (oral antibiotics). If the infection is being caused by an underlying skin condition, such as eczema, this may also need to be treated. For mild cases of impetigo that cover a small area, antibiotic cream is often recommended. This will usually need to be applied three or four times a day for seven days. Before applying the cream, wash any affected areas of skin with warm, soapy water and try to clean off any crusts that have developed. To reduce the risk of spreading the infection, it is also important that you wash your hands immediately after applying the cream or, if available, wear latex gloves while applying the cream. Side effects of antibiotic cream can include irritation, redness and itchiness in the area where the cream is applied. If symptoms have not improved after seven days of starting treatment, speak to your doctor about other possible treatment options. Antibiotic tablets Antibiotic tablets may be prescribed if the infection is more severe and widespread, or if the symptoms do not improve after using antibiotic cream. These will usually need to be taken two to four times a day for seven days. Common side effects of oral antibiotics include feeling sick, vomiting and diarrhoea. Speak to your doctor if your symptoms have not improved after seven days of treatment with antibiotic tablets.