Hi, I have read your question and I understand your concern. Orange coloration of hands happens mostly from your food intake. A change in your diet, or being a long time using the same foods like carrots, squash, sweet potatoes, pumpkins, spinach, beans, corn, and yams. Also red pigmented foods like tomatoes, beets, chili beans, and red fruit can give sometimes a deep orange color to your hands. Supplements and vitamins should be checked because they can add the amount of color from Beta Carotene. These are mild conditions treated by cutting of the abovementioned foods until the condition resolves by itself. This may take some time. But another condition that causes yellow hands is diabetes. I would suggest you to measure your fasting blood glucose levels two consecutive days, and if the levels are high, to go and see an Endocrinologist. Hope I have answered your question. If you have any further questions I will be happy to help. Wish you good health.